As the world’s population is aging, scientists at Kaiser Permanente Washington Health Research Institute (KPWHRI) are at the forefront of research to help older adults lead healthier lives.
Among the questions KPWHRI scientists have examined include whether getting regular exercise may reduce the risk of dementia, whether widely used medications increase the risk of falls and fractures, how long-term use of opioid pain medications affects the brain, and what approaches can help frail older adults become more physically active. Our research includes studies looking at brain health, physical activity and behavior change, medication safety, cardiovascular health, and chronic disease management, among other research areas. Now, new funding for aging research — especially research on Alzheimer’s and related dementias — offers even greater opportunities for KPWHRI scientists and their colleagues who work in health care systems.
Studies spanning decades
The institute has hosted several long-running cohort studies, including the Adult Changes in Thought (ACT) Study, a collaboration with the University of Washington. For more than 30 years, ACT researchers have studied risk factors for dementia, with the goal of finding new ways to delay or prevent Alzheimer’s disease and cognitive decline.
In May 2021, the National Institute of Aging awarded ACT a new grant totaling $55.6 million. With this additional funding, ACT will further examine how various health factors across our life span can impact later-life heart and brain health. The funding will allow ACT to examine the health impacts of sleep, physical activity, socio-economic factors, and prescription medications, as well as to examine brain imaging. In addition, ACT will continue to collect and study participants’ brains after their deaths to better understand how brain physiology is impacted by lifestyle factors.
Under the 5-year grant, ACT partners are expanding the existing cohort of 2,000 Kaiser Permanente Washington members to 3,000 and implementing new strategies to recruit a more diverse population. Additionally, as part of the grant, the ACT team is making its data more accessible to researchers nationwide. You can find out more about the ACT Study and collaborate with the team at www.actagingresearch.org.
Wide-ranging research
Scientists at KPWHRI are advancing age-related research in many other areas as well. Some highlights:
Shapiro LN, Gray MF, Freitag C, Taneja P, Kariya H, Crane PK, O'Hare AM, Vig EK, Taylor JS. Expanding the ethnographic toolkit: Using medical documents to include kinless older adults living with dementia in qualitative research. J Aging Stud. 2023 Jun;65:101140. doi: 10.1016/j.jaging.2023.101140. Epub 2023 May 10. PubMed
Williams ME, Elman JA, Bell TR, Dale AM, Eyler LT, Fennema-Notestine C, Franz CE, Gillespie NA, Hagler DJ Jr, Lyons MJ, McEvoy LK, Neale MC, Panizzon MS, Reynolds CA, Sanderson-Cimino M, Kremen WS. Higher cortical thickness/volume in Alzheimer's-related regions: protective factor or risk factor? Neurobiol Aging. 2023 May 9;129:185-194. doi: 10.1016/j.neurobiolaging.2023.05.004. PubMed
Ramirez M, Duran MC, Penfold RB, Pabiniak CJ, Hansen KE, Ornelas IJ. STAR-Caregivers virtual training and follow-up: A cultural adaptation for Latino caregivers of people with dementia. Transl Behav Med. 2023 Sep 12;13(9):625-634. doi: 10.1093/tbm/ibad028. PubMed
Gibbons LE, Power MC, Walker RL, Kumar RG, Murphy A, Latimer CS, Nolan AL, Melief EJ, Beller A, Bogdani M, Keene D, Larson EB, Crane PK, Dams-O'Connor K. Association of traumatic brain injury with late life neuropathological outcomes in a community-based cohort. J Alzheimers Dis. 2023 Apr 28. doi: 10.3233/JAD-221224. [Epub ahead of print]. PubMed
Merrihew GE, Park J, Plubell D, Searle BC, Keene CD, Larson EB, Bateman R, Perrin RJ, Chhatwal JP, Farlow MR, McLean CA, Ghetti B, Newell KL, Frosch MP, Montine TJ, MacCoss MJ. A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease. Sci Data. 2023 Apr 14;10(1):206. doi: 10.1038/s41597-023-02057-7. PubMed
Sascha Dublin, MD, PhDSenior Investigator |
Dori E. Rosenberg, PhD, MPHSenior Investigator |
Erin J. Bowles, MPHDirector, Collaborative Science |
Ellen O'Meara, PhDPrincipal Collaborative Scientist |
Melissa L. Anderson, MSPrincipal Collaborative Biostatistician |
Rod L. Walker, MSPrincipal Collaborative Biostatistician |
Laura Harrington, PhD, MPHAssistant Investigator |
Katie Coleman, MSPHDirector, ACT Center |
Robert Penfold, PhDSenior Investigator |
Marlaine Figueroa Gray, PhDAssistant Investigator |
Ben Balderson, PhDSenior Collaborative Scientist |
Jennifer C. Nelson, PhDDirector, Biostatistics; Senior Investigator |
Onchee Yu, MSPrincipal Collaborative Biostatistician |
Jessica Chubak, PhDSenior Investigator |
Yu-Ru Su, PhDAssociate Biostatistics Investigator |
Chloe Krakauer, PhDCollaborative Biostatistician |
Karen Wernli, PhDSenior Investigator |
Mikael Anne Greenwood-Hickman, MPHCollaborative Scientist |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Pamela A. Shaw, PhD, MSSenior Biostatistics Investigator |
Nicole M. Gatto, PhD, MPHPrincipal Collaborative Scientist |
Linda K. McEvoy, PhDSenior Investigator |
Lily N. Shapiro, PhDCollaborative Scientist |
James Bowen, MD
Neurologist
Swedish Medical Center
Paul Crane, MD, MPH
Professor, Internal Medicine
University of Washington
David R. Crosslin, PhD
Assistant Professor
Biomedical Informatics and Medical Education
Adjunct Faculty
Genome Sciences, Division of Medical Genetics
University of Washington
Kristen Dams-O'Connor, PhD
Associate Professor
Department of Rehabilitation Medicine
Icahn School of Medicine at Mt. Sinai
James Floyd, MD, MS
Assistant Professor, Department of Medicine
Shelly Gray, PharmD, MS, AGSF
Professor, Department of Pharmacy
University of Washington
Gail Jarvik, MD, PhD
Professor, Medical Genetics, Genome Sciences, Department of Medicine
University of Washington
Dirk Keene, MD, PhD
Department of Pathology
Harborview Medical Center
Zachary A. Marcum, PhD, PharmD
Assistant Professor, School of Pharmacy
University of Washington
Wayne McCormick, MD, MPH
Head of Gerontology and Geriatric Medicine
UW Medicine
Sue McCurry, PhD
Research Professor, Psychosocial and Community Health
University of Washington
Elizabeth Phelan, MD, MS
Associate Professor, Medicine/Gerontology and Geriatric Medicine
Harborview Medical Center
Adjunct Associate Professor, Health Services
University of Washington
Janelle S. Taylor, PhD
Professor, Department of Anthropology
University of Toronto
Linda Teri, PhD
Professor, Psychosocial & Community Health
Director, Northwest Research Group on Aging, Psychosocial and Community Health
University of Washington
Oleg Zaslavsky, PhD, MHA, RN
Assistant Professor Biobehavioral Nursing and Health Systems Department
Associate Director of Research, de Tornyay Center for Health Aging
School of Nursing, University of Washington