Laura B. Harrington, PhD, MPH

Harrington_Laura__205x293.jpg

“My research aims to improve our understanding of modifiable risk factors for cardiovascular events and sequelae and outcomes relevant to brain health, especially among women.”

Laura B. Harrington, PhD, MPH

Associate Investigator, Kaiser Permanente Washington Health Research Institute
Affiliate Assistant Professor, Department of Epidemiology, University of Washington School of Public Health
Assistant Professor, Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine

Biography

Laura B. Harrington, PhD, MPH, is an epidemiologist with expertise in cardiovascular epidemiology, the epidemiology of aging, and women’s health. As an Associate Investigator at the Kaiser Permanente Washington Health Research Institute (KPWHRI), her work leverages pharmacologic, medical-record based, lifestyle-based, and sex-specific exposure data to better understand associations between modifiable risk factors and cardiovascular and aging-related outcomes. She has particular interest and expertise in risk factors for incident and recurrent venous thromboembolism, in cardiovascular associations with brain health, and in sex-specific risk factors (e.g. endogenous sex hormone levels, vasomotor symptoms, hormone therapy use, characteristics of the menopause transition). She leads studies set in Kaiser Permanente Washington-based populations and existing epidemiologic cohort studies including the Women’s Health Initiative (WHI), the Adult Change in Thought (ACT) study, the Cardiovascular Health Study (CHS), the Nurses’ Health Studies (NHS) I and II, the Health Professionals Follow-up Study, and the Heart and Vascular Health (HVH) case-control study. Dr. Harrington is actively leading a new National Heart, Lung, and Blood Institute-funded inception cohort study of venous thromboembolism sequelae, the After Venous Thromboembolism Research (AFTER) Study.

Prior to joining KPWHRI in 2018, Dr. Harrington completed a postdoctoral fellowship at the Harvard T.H. Chan School of Public Health, earned her PhD in Epidemiology from the University of Washington, and her MPH in Epidemiology from the University of Michigan.

In addition to her role at KPWHRI, Dr. Harrington enjoys mentoring students and guest lecturing in her roles as Affiliate Assistant Professor of Epidemiology at the University of Washington School of Public Health and Assistant Professor of Health Systems Science at the Kaiser Permanente Bernard J. Tyson School of Medicine.

RESEARCH INTERESTS AND EXPERIENCE

  • Cardiovascular Health

    Venous thromboembolism; lifestyle-based risk factors (e.g., physical activity, sedentary behavior); pharmacologic risk factors; women’s cardiovascular health

  • Women's Health

    Endogenous sex hormones; oral contraceptive and hormone therapy use; characteristics of the menopause transition; adverse pregnancy outcomes and long-term women’s health outcomes

  • Aging & Geriatrics

    Cardiovascular risk factors and events in relation to brain health

  • Medication Use & Patient Safety

    Comparative safety studies; pharmacoepidemiology; prescription use in relation to cardiovascular and aging-related outcomes; oral contraceptive and hormone therapy use

Recent publications

Harrington LB, Cushing-Haugen KL, Nguyen S, Bellettiere J, LaMonte MJ, Eaton CB, Allison MA, Wallace RB, Manson JE, Jensen MK, Kabrhel C, Wellenius GA, Lee IM, Mukamal KJ, LaCroix AZ. Sedentary behaviors and venous thromboembolism risk among older women: The Objective Physical Activity and Cardiovascular Health (OPACH) study. J Thromb Haemost. 2025 Feb 20:S1538-7836(25)00110-2. doi: 10.1016/j.jtha.2025.02.014. Online ahead of print. PubMed

Greenwood-Hickman MA, Shapiro LN, Chen S, Crane PK, Harrington LB, Johnson K, LaCroix AZ, Lane LG, McCurry SM, Shaw PA, Rosenberg DE. Understanding resilience: Lifestyle-based behavioral predictors of mental health and well-being in community-dwelling older adults during the COVID-19 pandemic.  BMC Geriatr. 2024;24(1):676. doi: 10.1186/s12877-024-05251-3.  PubMed

Harrington LB, Benz L, Haneuse S, Johnson E, Coleman KJ, Courcoulas AP, Li RA, Theis MK, Cooper J, Chin PL, Grinberg GG, Daigle CR, Chang JH, Um SS, Yenumula PR, Getty JZ, Arterburn DE. Bariatric Surgery and the Long-Term Risk of Venous Thromboembolism: A Population-Based Cohort Study.  Obes Surg. 2024;34(6):2017-2025. doi: 10.1007/s11695-024-07236-y. Epub 2024 Apr 30.  PubMed

Harrington LB, Powers JD, Bayliss EA, Fortmann SP, Shortreed SM, Walker RL, Floyd JS, Kuntz J, Fuller S, Albertson-Junkans L, Lee MH, Temposky LA, Dublin S. Current use of estrogen-containing oral contraceptives or hormone therapy and risk of COVID-19 infection and hospitalization: A population-based cohort study. Am J Epidemiol. 2024 May 16:kwae066. doi: 10.1093/aje/kwae066. [Epub ahead of print]. PubMed

Harrington LB, Ehlert AN, Thacker EL, Jenny NS, Lopez O, Cushman M, Olson NC, Fitzpatrick A, Mukamal KJ, Jensen MK. Levels of procoagulant factors and peak thrombin generation in relation to dementia risk in older adults: The Cardiovascular Health Study.  Thromb Res. 2024;235:148-154. doi: 10.1016/j.thromres.2024.01.024. Epub 2024 Feb 4.  PubMed

 

Research

COVID-and-estrogen_op3_1col.jpg

COVID risks not meaningfully greater with estrogen-containing medications

Oral contraceptives, hormone therapy not linked to more severe COVID outcomes.

Research

VTE_after_bariatric_surgery_1col.jpg

Study finds bariatric surgery linked to substantially lower risk of blood clots long-term

Largest study to date helps patients weigh risks and benefits of surgery.

Healthy findings blog

QA_Laura-Harrington_1col.jpg

New grant boosts research on cardiovascular disease

Epidemiologist Laura B. Harrington, PhD, MPH, speaks about working in cardiovascular and aging research.