Gregory E. Simon, MD, MPH

Simon_Gregory_E_205x293.jpg

“We bring a practical approach to mental health research, working to break down barriers between research and real-world health care.”

Gregory E. Simon, MD, MPH

Senior Investigator, Kaiser Permanente Washington Health Research Institute
Psychiatrist, Washington Permanente Medical Group
Professor, Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine
Research Professor, Psychiatry and Behavioral Sciences, University of Washington

Biography

Greg Simon, MD, MPH, is a psychiatrist and senior investigator well-known for his extensive research on practical approaches to improving mental health care. He seeks to develop and evaluate effective real-world strategies that support better mental health and wellness.  Current areas of emphasis include identifying and assessing suicide risk, improving care for treatment-resistant depression, and early intervention for mental health conditions in children and youth.

Dr. Simon leads the Mental Health Research Network (MHRN), a consortium of research centers affiliated with 13 large health systems across the United States, including Kaiser Permanente Washington. This network, funded through a cooperative agreement with the National Institute of Mental Health, aims to improve the efficiency, relevance, and impact of mental health clinical and health services research. Now in its second five-year funding cycle, the MHRN is exploring a broad range of issues—including suicide prevention, improving heart health in people with serious mental illness, using electronic medical records to improve follow-up care for depression, and understanding the causes of racial and ethnic disparities in mental health care.

Dr. Simon and his MHRN colleagues are conducting several large studies across MHRN health systems, including:

  • A pragmatic trial in four health systems examining the effect of systematic outreach programs to prevent suicide attempt among people at high risk.
  • Using electronic health records from seven health systems to develop and validate machine learning models to identify people at high risk of suicidal behavior.
  • A pragmatic trial in two health systems evaluating electronic health record tools to reduce risk of cardiovascular disease in people with bipolar disorder and schizophrenia.
  • A rigorous evaluation of Zero Suicide care improvement programs in six health systems
  • Developing measures to assess quality of care for depression in two health systems.

Dr. Simon is an editor for the Cochrane Collaboration’s depression and anxiety review group, sits on the editorial board for General Hospital Psychiatry, and serves on the advisory board for the National Institutes of Health’s All of Us Program (formerly Precision Medicine Initiative).   Earlier, he served on the editorial boards of Psychiatric Services and Psychological Medicine and chaired the scientific advisory board for the Depression and Bipolar Support Alliance. Dr. Simon has practiced adult psychiatry in Kaiser Permanente Washington's Mental Health and Wellness Service since 1990 and is a research professor in psychiatry and behavioral sciences at the University of Washington.​​​

Research interests and experience

  • Mental Health

    Depression; bipolar disorder; suicide prevention; self-management; treatment adherence

  • Chronic Illness Management

    Comorbidity of mental health conditions with obesity, diabetes, heart disease, and substance use disorders.

Recent publications

Linden M, Lecrubier Y, Bellantuono C, Benkert O, Kisely S, Simon G. The prescribing of psychotropic drugs by primary care physicians: an international collaborative study. J Clin Psychopharmacol. 1999;19(2):132-40. PubMed

Lin EH, Simon GE, Katon WJ, Russo JE, Von Korff M, Bush TM, Ludman EJ, Walker EA. Can enhanced acute-phase treatment of depression improve long-term outcomes? A report of randomized trials in primary care. Am J Psychiatry. 1999;156(4):643-5. PubMed

Simon GE, Goldberg D, Tiemens BG, Ustun TB. Outcomes of recognized and unrecognized depression in an international primary care study. Gen Hosp Psychiatry. 1999;21(2):97-105. PubMed

Schulberg HC, Katon WJ, Simon GE, Rush AJ. Best clinical practice: guidelines for managing major depression in primary medical care. J Clin Psychiatry. 1999;60 Suppl 7():19-26; discussion 27-8. PubMed

Simon GE, Gureje O. Stability of somatization disorder and somatization symptoms among primary care patients. Arch Gen Psychiatry. 1999;56(1):90-5. PubMed

Von Korff M, Katon W, Unutzer J, Simon G, Bush T, Lin E, Walker E, Ludman E. Principles of population-based care of patients with bipolar disorder. Bipolar Disorders. 1999;1(Suppl):19. PubMed

Revicki DA, Simon GE, Chan K, Katon W, Heiligenstein J. Depression, health-related quality of life, and medical cost outcomes of receiving recommended levels of antidepressant treatment. J Fam Pract. 1998;47(6):446-52. PubMed

Schulberg HC, Katon W, Simon GE, Rush AJ. Treating major depression in primary care: an update of the Agency for Health Care Policy and Research Practice Guidelines. Arch Gen Psychiatry. 1998;55(12):1121-7. PubMed

Goldberg D, Privett M, Ustun B, Simon G, Linden M. The effects of detection and treatment on the outcome of major depression. Br J Gen Pract. 1998;48(437):1840-4. PubMed

Saunders K, Simon G, Bush T, Grothaus L. Assessing the feasibility of using computerized pharmacy refill data to monitor antidepressant treatment on a population basis: a comparison of automated and self-report data. J Clin Epidemiol. 1998;51(10):883-90. PubMed

 

Research

Integrating_suicide_care_in_primary_care_1col.jpg

Suicide attempts decreased after adding suicide care to primary care

Safety planning and risk screening improved outcomes for adult patients.

Research

Treatment_for_depression_1col.jpg

Can machine learning help treat depression more effectively?

A new grant funds modeling work to make personalized treatment possible.

Research

Lock_to_Live_Doctor_and_Patient_1col.jpg

Understanding adoption of Lock to Live, a decision aid supporting suicide prevention

KPWHRI research finds ways to increase use of a firearm safety tool.

Research

clozapine-story_1col.jpg

A medication that can relieve symptoms of psychosis is underused

Study finds that many patients who might benefit from clozapine don’t receive it.

Research

Mental-Health-Awareness-Month-2023_1col.jpg

Improving and advancing mental health care

KPWHRI researchers are contributing to better mental health care for people nationwide.