Vaccines save lives by protecting people against infectious diseases — polio, influenza, and pneumonia to name a few. Kaiser Permanente Washington Health Research Institute (KPWHRI) is working to protect communities through research to continually improve the safety and effectiveness of vaccines for infectious diseases of public health importance.
Central to this work is testing new vaccines against emerging diseases — such as COVID-19. In March 2020, KPWHRI gave the world’s first-ever injection of an investigational vaccine for COVID-19 in a phase 1 clinical trial led by Senior Investigator Lisa A. Jackson, MD, MPH. We continue to be at the forefront of efforts to understand and combat COVID-19. To learn more, see COVID-19 research at KPWHRI.
Successes over 3 decades of KPWHRI vaccine research include:
Our current research projects on vaccines and infectious diseases include:
Sumner KM, Yadav R, Noble EK, Sandford R, Joshi D, Tartof SY, Wernli KJ, Martin ET, Gaglani M, Zimmerman RK, Talbot HK, Grijalva CG, Chung JR, Rogier E, Coughlin MM, Flannery B. Anti-SARS-CoV-2 antibody levels associated with COVID-19 protection in outpatients tested for SARS-CoV-2, US Flu VE Network, October 2021-June 2022. medRxiv. 2023:2023.09.21.23295919. doi: 10.1101/2023.09.21.23295919. Preprint. PubMed
Branche AR, Rouphael NG, Diemert DJ, Falsey AR, Losada C, Baden LR, Frey SE, Whitaker JA, Little SJ, Anderson EJ, Walter EB, Novak RM, Rupp R, Jackson LA, Babu TM, Kottkamp AC, Luetkemeyer AF, Immergluck LC, Presti RM, Bäcker M, Winokur PL, Mahgoub +++. Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial. Nat Med. 2023;29(9):2334-2346. doi: 10.1038/s41591-023-02503-4. Epub 2023 Aug 28. PubMed
Irving SA, Crane B, Weintraub E, Kauffman TL, Brooks N, Patel SA, Razzaghi H, Belongia EA, Daley MF, Getahun D, Glenn SC, Hambidge SJ, Jackson LA, Kharbanda E, Klein NP, Zerbo O, Naleway AL. Influenza vaccination among pregnant people before and during the coronavirus disease 2019 (COVID-19) pandemic. Obstet Gynecol. 2023 Sep 1;142(3):636-639. doi: 10.1097/AOG.0000000000005285. Epub 2023 Aug 3. PubMed
Ahmed F, Nowalk MP, Zimmerman RK, Bear T, Grijalva CG, Talbot HK, Florea A, Tartof SY, Gaglani M, Smith M, McLean HQ, King JP, Martin ET, Monto AS, Phillips CH, Wernli KJ, Flannery B, Chung JR, Uzicanin A. Work attendance during acute respiratory illness before and during the COVID-19 pandemic, United States, 2018-2022. medRxiv 2023. PubMed
Kenigsberg TA, Goddard K, Hanson KE, Lewis N, Klein N, Irving SA, Naleway AL, Crane B, Kauffman TL, Xu S, Daley MF, Hurley LP, Kaiser R, Jackson LA, Jazwa A, Weintraub ES. Simultaneous administration of mRNA COVID-19 bivalent booster and influenza vaccines. Vaccine. 2023 Sep 7;41(39):5678-5682. doi: 10.1016/j.vaccine.2023.08.023. Epub 2023 Aug 19. PubMed
Lisa A. Jackson, MD, MPHSenior Investigator |
Jennifer C. Nelson, PhDDirector, Biostatistics; Senior Investigator |
Andrea J. Cook, PhDSenior Biostatistics Investigator |
Sascha Dublin, MD, PhDSenior Investigator |
Onchee Yu, MSPrincipal Collaborative Biostatistician |
Robert D. Wellman, MSPrincipal Collaborative Biostatistician |
Clarissa Hsu, PhDAssociate Investigator |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Noorie Hyun, PhDAssociate Biostatistics Investigator |
Pamela A. Shaw, PhD, MSSenior Biostatistics Investigator |
Annie Piccorelli, PhDSenior Collaborative Biostatistician |
Doug Opel, MD, MPH
University of Washington (UW) Department of Bioethics and Humanities; UW Department of Pediatrics; UW Medical Center
John Dunn, MD, MPH
Kaiser Foundation Health Plan of Washington
Elizabeth Lin, MD, MPH
Kaiser Foundation Health Plan of Washington Family Practice;
Kaiser Permanente Washington Health Research Institute