Vaccines save lives by protecting people against infectious diseases — polio, influenza, and pneumonia to name a few. Kaiser Permanente Washington Health Research Institute (KPWHRI) is working to protect communities through research to continually improve the safety and effectiveness of vaccines for infectious diseases of public health importance.
Central to this work is testing new vaccines against emerging diseases — such as COVID-19. In March 2020, KPWHRI gave the world’s first-ever injection of an investigational vaccine for COVID-19 in a phase 1 clinical trial led by Senior Investigator Lisa A. Jackson, MD, MPH. We continue to be at the forefront of efforts to understand and combat COVID-19. To learn more, see COVID-19 research at KPWHRI.
Successes over 3 decades of KPWHRI vaccine research include:
Our current research projects on vaccines and infectious diseases include:
Chung JR, Shirk P, Gaglani M, Mutnal MB, Nowalk MP, Geffel KM, House SL, Curley T, Wernli KJ, Kiniry EL, Martin ET, Vaughna IA, Murugan V, Lim ES, Saade E, Faryar K, Williams OL, Walter EB, Price AM, Barnes JR, DaSilva J, Kondor R, Ellington S, Flannery B. Late-season influenza vaccine effectiveness against medically attended outpatient illness, United States, December 2022-April 2023. Influenza Other Respir Viruses. 2024 Jun;18(6):e13342. doi: 10.1111/irv.13342. PubMed
Malden DE, Liu IA, Qian L, Sy LS, Lewin BJ, Asamura DT, Ryan DS, Bezi C, Williams JTB, Kaiser R, Daley MF, Nelson JC, McClure DL, Zerbo O, Henninger ML, Fuller CC, Weintraub ES, Saydah S, Tartof SY. Post-COVID conditions following COVID-19 vaccination: a retrospective matched cohort study of patients with SARS-CoV-2 infection. Nat Commun. 2024;15(1):4101. doi: 10.1038/s41467-024-48022-9. PubMed
Harrington LB, Powers JD, Bayliss EA, Fortmann SP, Shortreed SM, Walker RL, Floyd JS, Kuntz J, Fuller S, Albertson-Junkans L, Lee MH, Temposky LA, Dublin S. Current use of estrogen-containing oral contraceptives or hormone therapy and risk of COVID-19 infection and hospitalization: A population-based cohort study. Am J Epidemiol. 2024 May 16:kwae066. doi: 10.1093/aje/kwae066. [Epub ahead of print]. PubMed
Bi Q, Dickerman BA, Nguyen HQ, Martin ET, Gaglani M, Wernli KJ, Balasubramani GK, Flannery B, Lipsitch M, Cobey S. Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection. J Infect Dis. 2024 Apr 30:jiae220. doi: 10.1093/infdis/jiae220. [Epub ahead of print]. PubMed
Daley MF, Reifler LM, Shoup JA, Glanz JM, Lewin BJ, Klein NP, Kharbanda EO, McLean HQ, Hambidge SJ, Nelson JC, Naleway AL, Weintraub ES, McNeil MM, Razzaghi H, Singleton JA. Influenza vaccination accuracy among adults: Self-report compared with electronic health record data. Vaccine. 2024;42(11):2740-2746. doi: 10.1016/j.vaccine.2024.03.052. Epub 2024 Mar 25. PubMed
Lisa A. Jackson, MD, MPHSenior Investigator |
Jennifer C. Nelson, PhDDirector, Biostatistics; Senior Investigator |
Andrea J. Cook, PhDSenior Biostatistics Investigator |
Sascha Dublin, MD, PhDSenior Investigator |
Onchee Yu, MSPrincipal Collaborative Biostatistician |
Robert D. Wellman, MSPrincipal Collaborative Biostatistician |
Clarissa Hsu, PhDAssociate Investigator |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Noorie Hyun, PhDAssociate Biostatistics Investigator |
Pamela A. Shaw, PhD, MSSenior Biostatistics Investigator |
Annie Piccorelli, PhDSenior Collaborative Biostatistician |
Doug Opel, MD, MPH
University of Washington (UW) Department of Bioethics and Humanities; UW Department of Pediatrics; UW Medical Center
John Dunn, MD, MPH
Kaiser Foundation Health Plan of Washington
Elizabeth Lin, MD, MPH
Kaiser Foundation Health Plan of Washington Family Practice;
Kaiser Permanente Washington Health Research Institute